Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice.
Science (New York, N.Y.) January 15, 1999 C Ledent, O Valverde, G Cossu et al.
The function of the central cannabinoid receptor (CB1) was investigated by invalidating its gene. Mutant mice did not respond to cannabinoid drugs, demonstrating the exclusive role of the CB1 receptor in mediating analgesia, reinforcement, hypothermia, hypolocomotion, and hypotension. The acute effects of opiates were unaffected, but the reinforcing properties of morphine and the severity of...