Pharmacological and behavioral characterization of the 5-HT2A receptor in C57BL/6N mice.
Psychopharmacology June 2011 John P Dougherty, Vincent J Aloyo
The serotonin (5-HT) 2A receptor is implicated in numerous psychiatric disorders, making it an important, clinically relevant target. Despite the availability of transgenic mouse lines, the native mouse 5-HT(2A) receptor is not well-characterized. The goals of the current study were to determine 5-HT(2A) and 5-HT(2C) receptor densities in mouse cortex, establish a pharmacological profile of the...