Involvement of opioid system in cognitive deficits induced by ∆⁹-tetrahydrocannabinol in rats.
Psychopharmacology February 2012 Nobuaki Egashira, Naomi Manome, Kenichi Mishima et al.
Cannabis is a widely used illicit substance. ∆(9)-Tetrahydrocannabinol (THC), the major psychoactive component of cannabis, is known to induce cognitive deficits that closely resemble the impairment observed in schizophrenic patients. We previously reported that THC (6 mg/kg) impairs spatial memory in the eight-arm radial maze, and that this memory disturbance was reversed by the cannabinoid...