Progress in Neuro-Psychopharmacology and Biological Psychiatry
October 3, 2017
Mohini Ranganathan, Rajiv Radhakrishnan, Peter H. Addy et al.
Cannabis and agonists of the brain cannabinoid receptor (CB1R) produce acute memory impairments in humans. However, the extent to which cannabinoids impair the component processes of encoding and retrieval has not been established in humans. The objective of this analysis was to determine whether the administration of Δ9-Tetrahydrocannabinol (THC), the principal psychoactive constituent of...
Psychopharmacology
June 2014
Mohini Ranganathan, R Andrew Sewell, Michelle Carbuto et al.
A family history (FH) of alcoholism accounts for approximately 50% of the risk of developing alcohol problems. Several lines of preclinical evidence suggest that brain cannabinoid receptor (CB1R) function may mediate the effects of alcohol and risk for developing alcoholism including the observations that reduced CB1R function decreases alcohol-related behaviors and enhanced CB1R function...
The International Journal of Neuropsychopharmacology
October 2012
Mohini Ranganathan, Michelle Carbuto, Gabriel Braley et al.
Although a wealth of preclinical evidence indicates an interplay between the μ-opioid (MOR) and cannabinoid 1 receptor (CB1R) systems, the precise nature of the cross modulation in humans is unclear. The objective of this study was to evaluate the effects of pretreatment with the MOR antagonist, naltrexone, on the subjective, behavioural and cognitive effects of the CB1R agonist,...
Neuropsychopharmacology
June 2012
Deepak Cyril D'Souza, Daniel J Fridberg, Patrick D. Skosnik et al.
Cannabinoids induce a host of perceptual alterations and cognitive deficits in humans. However, the neural correlates of these deficits have remained elusive. The current study examined the acute, dose-related effects of delta-9-tetrahydrocannabinol (Δ⁹-THC) on psychophysiological indices of information processing in humans. Healthy subjects (n=26) completed three test days during which they...
Psychopharmacology
February 2012
Michelle Carbuto, R Andrew Sewell, Ashley H Williams et al.
Delta-9-tetrahydrocannabinol (THC) is one of the few cannabinoid receptor ligands that can be used to probe the cannabinoid system in humans. Despite increasing interest in the cannabinoid receptor system, use of intravenous THC as a research tool has been limited by concerns about its abuse liability and psychoactive effects. This study aims to evaluate the safety of all intravenous THC...