Glutamate modulators as novel interventions for mood disorders.
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) September 2005 Sanjay J Mathew, Kathryn Keegan, Lisa Smith
Recent evidence suggests that critical molecules in neurotrophic signaling cascades are long-term targets for currently available monoaminergic antidepressants. As chronic and severe mood disorders are characterized by impairments in neuronal resilience, pharmacological strategies that subserve a neuroprotective function might alter disorder pathophysiology and modify disease progression....