[The role of the glutamatergic system in pathophysiology and pharmacotherapy for depression: preclinical and clinical data].
Fortschritte der Neurologie-Psychiatrie April 2011 G Paslakis, P Gass, M Deuschle
An increasing significance has been attributed to the glutamatergic system in the pathophysiology of affective disorders. Glutamate is the most important excitatory neurotransmitter in the central nervous system. Glia cells are crucial regulators of the glutamatergic metabolism. Several studies have reported a dysfunction or reduced number of glia cells in patients suffering from depression....