Role of glutamate receptors and glial cells in the pathophysiology of treatment-resistant depression.
Progress in Neuro-Psychopharmacology and Biological Psychiatry October 3, 2016 Yong‐Ku Kim, Kyoung-Sae Na
Treatment-resistant depression (TRD) causes substantial socioeconomic burden. Although a consensus on the definition of TRD has not yet been reached, it is certain that classic monoaminergic antidepressants are ineffective for TRD. One decade ago, many researchers found ketamine, an N-methyl-d-aspartate receptor (NMDAR) antagonist, to be an alternative to classic monoaminergic antidepressants....
DOI: 10.1016/j.pnpbp.2016.03.009 (opens in new tab)
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Ketamine
Treatment-resistant depression
Glia
Glutamate receptors
+1