Abstract LB-403: A Phase 0 microdosing clinical trial to identify chemoresistance
Cancer Research April 15, 2011 Chong-Xian Pan, Sisi Wang, Ralph De Vere White et al.
Abstract BACKGROUND: As alkylating agents, platinum (Pt) analogs kill cancer cells mainly through induction of DNA damage. We hypothesize that low levels of Pt-induced DNA damage are predictive of chemoresistance. Accelerator mass spectrometry (AMS) is an ultrasensitive method for measuring radiocarbon with 10−18∼21 mole sensitivity. By measuring 14C bound to DNA, AMS detects...