Experimental and Clinical Psychopharmacology
February 2023
Jiyoung Ma, In Kyoon Lyoo, Perry F Renshaw et al.
Cannabis has been widely used medically and recreationally for centuries. With a renewed interest in the therapeutic use of cannabinoids, which are active components of Cannabis sativa, it has become important to understand the cannabinoids' neurobiological mechanisms related to both therapeutic and harmful effects. This review summarizes the effects of two major cannabinoids,...
Drug and Alcohol Dependence
April 1, 2022
Punitha Subramaniam, Andrew P Prescot, Erin McGlade et al.
Adolescent marijuana (MJ) use has been associated with alterations in brain structure and function as well as behavior. Examination of neurochemical correlates such as GABA (gamma-aminobutyric acid) and Glx (glutamate + glutamine) in MJ users remains limited. Impulsivity, identified as a risk factor and consequence of MJ use, has been associated with GABA and Glx levels in healthy and clinical...
Neuroimage
July 1, 2011
Andrew P Prescot, Allison E Locatelli, Perry F Renshaw et al.
Converging evidence from neuroimaging and neuropsychological studies indicates that heavy marijuana use is associated with cingulate dysfunction. However, there has been limited human data documenting in vivo biochemical brain changes after chronic marijuana exposure. Previous proton magnetic resonance spectroscopy studies have demonstrated reduced basal ganglia glutamate and dorsolateral...
Psychopharmacology
December 2004
F Gerard Moeller, Joel L. Steinberg, Donald M Dougherty et al.
Methylene-dioxymethamphetamine (MDMA) is known to cause degeneration of serotonin nerve terminals after acute doses in animals. Similarly, behavioral studies in human MDMA users regularly find abnormalities in memory, mood, and impulse control. However, studies of brain function using brain imaging in MDMA users have been less consistent. The purpose of this study was to determine, using...