Background Deeper understanding of ketamine’s mechanism of action would contribute to the discovery of novel therapeutic targets with fast-onset actions. To gain insight on the mechanism underlying the antidepressant-like effects of ketamine, we focused on perineuronal nets (PNNs), an extracellular matrix structure that surrounds fast-spiking parvalbumin-positive interneurons and regulates...
OBJECTIVE To use functional MRI to assess the effect of acupuncture on brain resting-state functional connectivity in breast cancer patients with hot flashes. METHODS A total of 24 breast cancer patients experiencing hot flashes (BC-HF) underwent 5 weeks of acupuncture treatment and follow-up at 4-6 months after therapy. The control groups included 35 patients with breast cancer without hot...