Confirmatory efficacy and safety of circular breathwork versus progressive muscle relaxation in trauma-exposed adults with subclinical depressive symptoms (RESET study HU Berlin, Germany).
August 26, 2026 Isabel Dziobek, Barbara Breitenstein, Martha N. Havenith et al.
This preregistration specifies the confirmatory efficacy and safety analyses for the main paper of the EX_WELL arm of the RESET Berlin trial. The trial compares circular breathwork against progressive muscle relaxation (PMR), an active, structurally matched comparator, in adults with trauma exposure and subclinical depressive symptomatology. The primary outcome is mental well-being (WEMWBS)....