The Role of Pain Frequency in the Divergent Associations Between Cannabis Use and Default Mode Network Connectivity
Tracy Brown, Che Liu, Emese Kroon et al.
Abstract Background Chronic pain is one of the most common reasons for medicinal cannabis use, yet the neural mechanisms underlying cannabis-related modulation of pain remain poorly understood. Both pain and cannabis use independently alter functional connectivity within the brain’s default mode network (DMN) that modulate interoception and self-referential aspects of pain processing. The goal...