Sex-sensitive serotonergic signaling in psychedelic pharmacology.
TIPS - Trends in Pharmacological Sciences August 1, 2026 S. Nasini, B. Barzon, A. Casile et al.
Classic serotonergic psychedelics act primarily via 5-HT2A receptor agonism, yet their therapeutic effects and biological responses are heterogeneous. Biological sex remains an underexamined source of this variability because many clinical and preclinical studies have not been designed to test sex-by-treatment effects. Recent preclinical findings, together with more limited human evidence,...