Background/Objectives Retrospective survey and clinical chart review studies have demonstrated the real-world effectiveness of ibogaine and 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in addressing a range of mental health challenges among military Veterans in the United States (US), but no prospective research study has examined safety and effectiveness in this population. Design/Methods We...
Psilocybin-assisted therapy (PAT) shows promise for treating PTSD in adults but hasn't been studied in U.S. military Veterans, who face higher symptom severity and suicide risk. This open-label pilot trial evaluated the safety and feasibility of PAT in Veterans with severe, treatment-resistant PTSD. The clinical trial was pre-registered at ClinicalTrials.gov (NCT05554094). The eligibility...