Salvinorin A in humans: A systematic review of pharmacokinetics, pharmacodynamics, and safety
Journal of Psychopharmacology August 25, 2026 Wolfgang Emanuel Zürrer, Johann Liesner, David Brüschweiler et al.
, is a highly selective κ-opioid receptor agonist and a rare example of a κ-opioid receptor-mediated psychedelic drug. Preclinical work of salvinorin A has shown promising effects in neuropsychiatric animal models. However, human studies remain heterogeneous and fragmented, highlighting the need for synthesis. Thus, we conducted a systematic review to synthesize available human studies of...