Electroconvulsive Therapy and (Es)Ketamine in Treatment-Resistant Depression: A Review of Current Evidence
European Psychiatry June 1, 2026 J. Marta, Â. Ferreira, C. Batista et al.
Introduction Treatment-Resistant Depression (TRD) is a major clinical challenge, affecting about 30% of patients with major depressive disorder. It is associated with high morbidity and mortality, reflected in increased suicide risk, hospitalizations, and impaired quality of life. Electroconvulsive Therapy (ECT) remains the therapeutic gold standard, particularly in severe cases with psychotic...