Brain-wide reconfiguration of burst firing by psilocybin reveals 5-HT2A-dependent circuit dynamics
bioRxiv August 19, 2026 D. Momi, Y. Nahas, D. Wyrick et al. preprint
Psilocybin produces rapid and lasting therapeutic effects, yet how 5-HT2A receptor activation reshapes brain-wide circuit dynamics during acute drug administration remains poorly understood. Using simultaneous multi-region Neuropixels recordings of 46,360 single units from 35 mice, together with scalp electroencephalography (EEG), pupillometry, and locomotion monitoring, we provide a...