COMPARATIVE EFFICACY OF ELECTROCONVULSIVE THERAPY, KETAMINE, AND OTHER PHARMACOLOGICAL APPROACHES REGARDING NEUROBIOLOGICAL ADAPTATIONS IN TREATMENT RESISTANCE
Artefactum August 6, 2026 Laura Alves Dutra, Anne Karolyne Alves Martins, Marina Camarão Oliveira et al.
Introduction:Treatment-resistant depression (TRD) is defined by the persistence of depressive symptoms despite at least two adequate trials with different classes of antidepressants. Limitations of traditional monoaminergic drugs have driven the search for rapid-acting, innovative interventions such as ketamine and electroconvulsive therapy (ECT), which target neuroplasticity and the...