HealthcareAugust 26, 2026Mostafa A. Sayed Ali, Palanisamy Amirthalingam, Hanan Alshareef et al.
Background/Objectives: This study evaluated the real-world effectiveness and safety of intranasal esketamine plus oral antidepressants compared with venlafaxine-based oral antidepressant therapy in adults with moderate-to-severe treatment-resistant depression (TRD). Methods: This retrospective cohort study used electronic medical records from a mental health hospital between January 2023 and...