Psychedelic-informed Therapeutics and Functional Decoupling: Toward Experience-independent Rapid-acting Antidepressants
Clinical Psychopharmacology and Neuroscience July 31, 2026 Won-Seok Choi, Moon‐Soo Lee, Mi Kyoung Seo et al.
Major depressive disorder remains a leading cause of global disability, and many patients show limited response to conventional antidepressants.Increasing evidence suggests that a substantial subgroup exhibits chronic low-grade inflammation, which may constrain synaptic plasticity and contribute to persistent depressive symptoms.In this review, we propose that depression can be conceptualized...