Single dose IV ketamine for adolescent suicidal ideation in the emergency department: a pilot randomized trial
BMC Psychiatry April 6, 2026 Michael Schlegelmilch, Amy C. Plint, Nicholas Barrowman et al.
BACKGROUND: Suicidal ideation (SI) is a common reason for emergency department (ED) visits by adolescents. While intravenous (IV) ketamine rapidly reduces SI in adults, its efficacy in adolescents remains unstudied. We assessed the feasibility of a trial of a single dose IV ketamine to reduce adolescent SI in the ED. METHODS: This double-blind, randomized, placebo-controlled pilot trial was...