Effects of ketamine and propofol on muscarinic plateau potentials in rat neocortical pyramidal cells.
PLoS One 2025 Anne S. Fleiner, Daniel Kolnier, Nicholas Hagger-Vaughan et al. 1 citation
Propofol and ketamine are widely used general anaesthetics, but have different effects on consciousness: propofol gives a deeply unconscious state, with little or no dream reports, whereas vivid dreams are often reported after ketamine anaesthesia. Ketamine is an N-methyl-D-aspartate (NMDA) receptor antagonist, while propofol is a γ-aminobutyric-acid (GABAA) receptor positive allosteric...