Zixuan Song

2 papers in the library · 1 citation · publishing 2023-2025

Papers

Qualitative confirmation of 30 phencyclidine analogs in human blood and urine using GC-HRMS and a self-built library search.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences February 1, 2025 Zixuan Song, Zhenshuo Guo, Yiling Tang et al. 1 citation

A new high-throughput screening method using gas chromatography–high-resolution mass spectrometry (GC-HRMS) identifies 30 phencyclidine analogs in human blood and urine. After a simple extraction with ethyl ether and buffer, analytes are identified using a self-built library and reference spectra; isomers are differentiated by exact molecular mass and retention time. The method shows no interferences, recovery ranges from 30% to 123%, and detection limits from 0.05 to 5 ng/mL. Applied to 800 authentic forensic cases, it detected four analogs—2-F-2-oxo-PCE, 3-MeO-PCE, O-PCE, and 2-FDCK—demonstrating suitability for sensitive, fast high-throughput drug screening.

DOI: 10.1016/j.jchromb.2025.124464 Full text Blood samples Gc-hrms Phencyclidine analogs Self-built library +5

In vitro and in vivo metabolism of 3-MeO-PCE in human liver microsomes, a zebrafish model, and two human urine samples based on liquid chromatography-high resolution mass spectrometry.

Drug Testing and Analysis May 1, 2023 Linhao Xu, Xinze Liu, Zixuan Song et al.

3-Methoxyeticyclidine (3-MeO-PCE), a substance related to phencyclidine (PCP), binds more strongly to NMDA receptors than PCP and has been linked to fatal overdoses. Using zebrafish and human liver microsomes, researchers identified 14 metabolites of 3-MeO-PCE through metabolic pathways including hydroxylation, O-demethylation, N-dealkylation, dehydrogenation, and conjugation. Urine samples from known consumers revealed 3-MeO-PCE and three metabolites. The hydroxylation product, M2, is recommended as a biomarker to confirm 3-MeO-PCE intake in clinical and forensic settings.

DOI: 10.1002/dta.3488 Medicine Chemistry