Addictive BehaviorsAugust 1, 2026Sarret Seng, Chizimuzo T C Okoli, Lovoria B Williams et al.
Metacognition - the capacity to monitor, interpret, and regulate cognitive processes - is essential for adaptive behavioral regulation. Evidence on how substance use relates to metacognitive functioning remains heterogeneous across substances and study designs. This systematic review synthesized evidence examining the relationship between substance use and metacognition among adults. Following...
Cannabidiol (CBD), a constituent of cannabis with few psychoactive effects, has been reported in some studies to attenuate certain aspects of Δ(9)-tetrahydrocannabinol (THC) intoxication. However, most studies have tested only one dose of CBD in combination with one dose of oral THC, making it difficult to assess the nature of this interaction. Further, the effect of oral CBD on smoked cannabis...
Opioid dependence remains a significant public health problem worldwide with only three FDA-approved treatments, all targeting the mu-opioid receptor. Dronabinol, a cannabinoid (CB) 1 receptor agonist, is currently under investigation as a novel opioid withdrawal treatment. This study reports on safety outcomes of dronabinol among adults in opioid withdrawal. Twelve adults physically dependent...