Translational Regulation in Excitatory Neurons Controls Stress Reactivity and the Antidepressant Response to Ketamine
2026 Sebastian Baranyi Nicholls
Major depressive disorder (MDD) is a leading cause of disability worldwide, with nearly one-third remaining treatment-resistant. Chronic stress is a major risk factor for MDD, whereas acute stress is adaptive and mediated by hypothalamic-pituitary-adrenal axis activation. Ketamine produces rapid antidepressant effects, partly through mammalian target of rapamycin complex 1 (mTORC1) signalling,...