Preclinical studies and anecdotal case reports support the potential therapeutic benefit of low-dose oral ketamine as a treatment of clinical symptoms in Rett syndrome (RTT); however, no controlled studies have been conducted in RTT to evaluate safety, tolerability and efficacy. This was a sequentially initiated, dose-escalating cohort, placebo-controlled, double blind, randomized sequence,...
A rock engraving site at Kalabasput in the Upper Karoo, South Africa, includes an unusual set of engravings featuring vultures. In relation to the ‘frequently depicted’ subject matter of South African rock art – such as eland and ostrich – images of vultures are rare. The site provides an opportunity for considering these unusual images relative to a background of “shared, transcending beliefs...