RTI-4793-14, a new ligand with high affinity and selectivity for the (+)-MK801-insensitive [3H]1-]1-(2-thienyl)cyclohexyl]piperidine binding site (PCP site 2) of guinea pig brain.
Synapse (New York, N.Y.) January 1, 1994 C B Goodman, D N Thomas, A Pert et al.
The novel compound RTI-4793-14 binds selectively and with high affinity to a brain site (PCP site 2) that is insensitive to MK-801 and may be associated with biogenic amine transporters. In contrast, MK-801 binds with high affinity only to PCP site 1 (associated with NMDA receptors) and potently blocks NMDA responses, while PCP binds with high affinity to both sites and is moderately potent across several transporter-related measures. RTI-4793-14 is the first selective, high-affinity ligand for PCP site 2.