Proteomic systems evaluation of the molecular validity of preclinical psychosis models compared to schizophrenia brain pathology.
Schizophrenia Research November 1, 2016 David A Cox, Michael G Gottschalk, Hendrik Wesseling et al.
Pharmacological and genetic rodent models of schizophrenia play an important role in the drug discovery pipeline, but quantifying the molecular similarity of such models with the underlying human pathophysiology has proved difficult. We developed a novel systems biology methodology for the direct comparison of anterior prefrontal cortex tissue from four established glutamatergic rodent models...