Proteomic systems evaluation of the molecular validity of preclinical psychosis models compared to schizophrenia brain pathology.
Schizophrenia Research November 1, 2016 David A Cox, Michael G Gottschalk, Hendrik Wesseling et al.
A systems biology approach compared protein changes in anterior prefrontal cortex tissue from four glutamatergic rodent models of schizophrenia and from human post-mortem schizophrenia patients. Liquid chromatography-tandem mass spectrometry proteomic profiling identified five functional domains of the disease, including "development and differentiation," represented across all rodent models. Kernel-based machine learning quantified that the chronic phencyclidine (PCP) model most closely resembled schizophrenia brain changes for four of these domains. The authors argue this methodology helps evaluate which rodent model best recapitulates neuropathological features of schizophrenia, supporting efforts to link functional behavioral dimensions with distinct biological processes.