PsychopharmacologyFebruary 1, 1995P J Armstrong, C Morton, W Sinclair et al.
In this six-period randomised double-blind study, 12 healthy volunteers inhaled mixtures of nitrous oxide at concentrations of 0% (placebo); 3%, 5%, 7%, 10%, and 15% in oxygen. Each concentration was inhaled for 55 min, each period being on a separate day. The order of treatments was randomised using a Latin-Square design. The effects of nitrous oxide were assessed using a battery of...
This study compared the sensitivity of various measures of attention to the effects of CNS depression, using a randomised single-blind two-period cross-over study. Nineteen healthy volunteers, 10 males and nine females, aged 20-49 took part in a single session in which they inhaled 15% nitrous oxide in oxygen or 100% oxygen (placebo) through a face-mask for 45 min, followed by a 10-min interval...