Ketamine Therapy in Psychiatry: A Comprehensive Review
Journal of Psychiatric Nursing August 30, 2025 Asif Khan, Satyaveer *, Shrikant K. Nair et al.
Ketamine, originally used as an anesthetic, has shown rapid antidepressant effects, especially for treatment-resistant depression. This review examines its mechanisms as an NMDA receptor antagonist, therapeutic uses, clinical efficacy, and safety concerns. The authors argue that while ketamine offers promise, its use raises ethical, regulatory, and long-term safety issues requiring further research and careful implementation.