Effects of sub-anesthetic doses of esketamine on immune function and postoperative negative emotions in acoustic neuroma patients: a randomized clinical trial.
Annals of medicine December 1, 2026 Zheping Chen, Yaozhu Wang, Peilin Cong et al.
A double-blind randomized trial found that perioperative sub-anesthetic esketamine reduced postoperative depression and anxiety and improved sleep quality in patients undergoing acoustic neuroma surgery. The incidence of depression on postoperative day 1 was 7.7% in the esketamine group versus 31.6% in the placebo group, and on day 3 it was 0.0% versus 15.8%. Anxiety and sleep disturbances also significantly decreased. No significant differences were observed in immune function, postoperative pain scores, or adverse events between groups.