The ketamine chameleon: history, pharmacology, and the contested value of experience.
Expert Review of Clinical Pharmacology March 1, 2025 Danny Diep, Sara de la Salle, Julien Thibault Lévesque et al. 8 citations
Since its synthesis in 1962, ketamine has been widely used in diverse medical contexts, from anesthesia to treatment-resistant depression. However, interpretations of ketamine's subjective effects remain polarized. Biomedical frameworks typically construe the drug's experiential effects as dissociative or psychotomimetic, while psychedelic paradigms emphasize the potential therapeutic merits of...