Younis Abiedalla

2 papers in the library · publishing 2020-2021

Papers

GC–MS and GC–IR analysis of methylenedioxyphenylalkylamine analogues of the psychoactive 25X-NBOMe drugs

May 1, 2021 Younis Abiedalla, Ahmad J. Almalki, J. Deruiter et al.

Twelve secondary amines structurally similar to NBOMe drugs were synthesized and analyzed using gas chromatography–mass spectrometry and vapor-phase infrared spectroscopy. These compounds contain a methylenedioxy group fused to the aromatic ring of the phenethyl moiety. One subseries are N-methoxybenzyl analogues of MDA; another subseries have bromine and two methoxy groups on the benzyl side. The compounds are not known drugs of abuse, and the study provides data to distinguish them from current NBOMe drugs. The elution order on a specific GC phase was determined for regioisomers, and characteristic fragmentation patterns in mass spectra and infrared spectra confirmed substitution positions.

DOI: 10.1016/j.forc.2021.100314 Chemistry

GC–MS analysis of N-(bromodimethoxybenzyl)-2-, 3-, and 4-methoxyphenethylamines: Inverse analogues of the psychoactive 25B-NBOMe drug

September 23, 2020 Ahmad J. Almalki, C. Clark, Younis Abiedalla et al.

Nine regioisomeric compounds, derivatives of 25B-NBOMe with reversed aromatic ring substitution, were synthesized and analyzed. Their electron ionization mass spectra showed two major bromine-containing ions at m/z 229/231 and 258/260, and two non-brominated fragments at m/z 91 and 121. The relative abundance of m/z 91 was higher for 2-methoxyphenethylamine isomers, while m/z 121 was higher for the 4-methoxy isomer. Gas chromatography separated the isomers by methoxy position, with 2-methoxy eluting first and 4-methoxy last. Trifluoroacetamide derivatives of 2-bromo-4,5-dimethoxybenzyl isomers produced unique fragment ions from bromine displacement, confirmed with model compounds.

DOI: 10.1016/j.forc.2020.100277 Chemistry