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Hiroshi Ikegaya

2 papers in the library · publishing 2018

Papers

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5-HT2A Receptor Agonist-Induced Hyperthermia Is Induced via Vasoconstriction by Peripheral 5-HT2A Receptors and Brown Adipose Tissue Thermogenesis by Peripheral Serotonin Loss at a High Ambient Temperature.

The Journal of pharmacology and experimental therapeutics November 1, 2018 Mami Nakamura, Kaori Shintani-Ishida, Hiroshi Ikegaya

Recreational drugs such as 3,4-methylenedioxymethamphetamine and cocaine induce hyperthermia, which is affected by ambient temperature. 2-(4-Bromo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25B-NBOMe), a selective agonist of 5-HT2A receptor used as a recreational drug, reportedly induces hyperthermia. This study aimed to verify whether 25B-NBOMe induces ambient temperature-dependent...

Experimental Study on the Postmortem Redistribution of the Substituted Phenethylamine, 25B‐NBOMe

Journal of Forensic Sciences March 1, 2018 Kaori Shintani-Ishida, Kanju Saka, Mami Nakamura et al.

Abstract2‐(4‐Bromo‐2,5‐dimethoxyphenyl)‐N‐(2‐methoxybenzyl)ethanamine (25B‐NBOMe) is a substituted phenethylamine, which has become highly prevalent worldwide since 2014. Recently, in an autopsy case involving fatal 25B‐NBOMe intoxication, we found the postmortem increase of 25B‐NBOMe concentration in the cardiac blood approximately 2 days after death. The aim of this study was to investigate...