Ketamine improved depressive‐like behaviors via hippocampal glucocorticoid receptor in chronic stress induced‐ susceptible mice
Behavioural Brain Research May 1, 2019 Wei Wang, Le Liu, Xiu Yang et al.
HighlightsSusceptible mice showed depressive‐like behaviors upon chronic social defeat stress.Plasma corticosterone concentration might predict susceptibility to chronic stress.Abnormal glucocorticoid receptor expression was associated with susceptibility.Ketamine exerted antidepressant effect via normalizing HPA axis response. &NA; Chronic stress is an important factor for depression. Most...