The positive allosteric modulator of the mGlu2 receptor JNJ-46356479 partially improves neuropathological deficits and schizophrenia-like behaviors in a postnatal ketamine mice model.
Journal of Psychiatric Research April 26, 2020 A. Martínez-Pinteño, Susana García-Cerro, S. Mas et al.
A positive allosteric modulator of the metabotropic glutamate receptor 2, JNJ-46356479, partially reversed spatial working memory deficits and social motivation and memory impairments in a mouse model of schizophrenia induced by postnatal ketamine. The ketamine-treated mice also showed reduced parvalbumin-positive interneurons in the medial prefrontal cortex and dentate gyrus, along with increased c-Fos expression in the hippocampus; JNJ treatment normalized these neural markers. The results suggest that targeting mGluR2 could help improve cognitive and negative symptoms related to schizophrenia.