Antidepressant-like effects of ketamine in a mouse model of serotonergic dysfunction.
Neuropharmacology February 12, 2020 C. Wilson, Shanshan Li, Anthony J. Hannan et al.
Traditional monoaminergic treatments of depression frequently exhibit suboptimal tolerability and effectiveness. The 'short' (s) allele variant of 5-HTTLPR is known to compromise transcriptional efficacy of the serotonin transporter (5-HTT) and can reduce treatment response to traditional antidepressants (e.g. selective serotonin reuptake inhibitors or SSRIs). This study sought to establish the...