Effects of (S)-ketamine on depression-like behaviors in a chronic variable stress model: a role of brain lipidome
Frontiers in Cellular Neuroscience February 15, 2023 Cui-Hong Zhou, Xinxin Zhao, Xinxu Ma et al.
A single sub-anesthetic dose of (S)-ketamine reversed depressive-like behaviors in mice subjected to chronic variable stress. The stress procedure altered lipid compositions in the hippocampus and prefrontal cortex, particularly affecting sphingolipids, glycerolipids, and fatty acyls. (S)-ketamine partially normalized these lipid disturbances, especially in the hippocampus, suggesting that region-specific modulation of the brain lipidome contributes to its antidepressant effects.