HCN channel inhibitor induces ketamine-like rapid and sustained antidepressant effects in chronic social defeat stress model
Neurobiology of Stress August 1, 2023 Min Cai, Yingbo Zhu, M. R. Shanley et al.
Repeated, long-term (weeks to months) exposure to standard antidepressant medications is required to achieve treatment efficacy. In contrast, acute ketamine quickly improves mood for an extended time. Recent work implicates that hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are involved in mediating ketamine's antidepressant effects. In this study, we directly targeted HCN...