A fingertip force control task that adjusts challenge to match personal skill can induce flow and track its rapid fluctuations. Eight performance metrics extracted from force sequences differed significantly across flow states. A learning-based decoder predicted continuous flow intensity from these metrics, correlating with self-reported flow at r=0.81. Decoded results revealed rapid oscillations in flow between sparse self-report probes, demonstrating high-temporal-resolution tracking of flow dynamics.
Fifteen metabolites of the designer hallucinogen 25I-NBOMe were identified in mouse liver microsomal preparations and in urine from two intoxicated patients. One patient's urine contained the parent drug and all fifteen metabolites; the other contained only three O-desmethyl metabolites. Two major urinary metabolites were synthesized. The authors recommend using β-glucuronidase hydrolysis before screening and using the metabolite M5 as the primary biomarker for detecting 25I-NBOMe use.