Multimodal imaging of hallucinogens 25C- and 25I-NBOMe on blotter papers.
Drug Testing and Analysis April 1, 2020 Elias Lützen, Michael Holtkamp, Imke Stamme et al.
Blotter papers sold as LSD sometimes contain cheaper phenethylamine derivatives like 25I-NBOMe and 25C-NBOMe, which can cause severe intoxication. Using three imaging techniques and liquid chromatography-mass spectrometry, the manufacturing process was elucidated. Micro x-ray fluorescence was the fastest and cheapest method for identifying the compounds, requiring no sample preparation. Laser ablation-inductively coupled plasma-optical emission spectroscopy provided three-dimensional elemental information, supporting the conclusion that manufacturers spray the compounds onto the paper. Matrix assisted laser desorption ionization-mass spectrometry imaging showed the molecular distribution of both analytes. Quantitative results revealed a heterogeneous distribution of the drugs on the blotter paper, implying an inherent risk of overdosing for consumers.