In vitro and in vivo metabolism of 3-MeO-PCE in human liver microsomes, a zebrafish model, and two human urine samples based on liquid chromatography-high resolution mass spectrometry.
Drug Testing and Analysis May 1, 2023 Linhao Xu, Xinze Liu, Zixuan Song et al.
3-Methoxyeticyclidine (3-MeO-PCE), a phencyclidine-type substance, has a higher N-methyl-D-aspartate receptor (NMDAR) receptor binding affinity than phencyclidine (PCP) and an involvement in fatal intoxication cases. The aim of this study was to identify new biomarkers and biotransformation pathways for 3-MeO-PCE. In vitro models were established using zebrafish and human liver microsomes for...