Evaluation of Ketamine after subacute low dosage Lipopolysaccharide-activated Microglia produced depressive-like phenotype in mice
Research Journal of Pharmacy and Technology April 22, 2024 Shuvranshu Praharaj, Vandurayanpet Kaliyamoorthy Kalaichelvan, Vedigounder Murugan et al.
In a mouse model of depression induced by lipopolysaccharide, ketamine reduced depressive-like behaviors such as increased immobility in the forced swim test and anhedonia, and it also decreased Iba-1 immunoreactivity, a marker of microglial activation. However, ketamine did not reduce the number of microglia or CD11b-positive cells in the hippocampus, nor did it affect the relative weights of the spleen and thymus. These findings suggest that ketamine improves depressive-like behavior and some aspects of neuroinflammation but does not modulate the overall number of microglia or certain immune cell markers in the hippocampus.