Evidências clínicas da eficácia da psilocibina no tratamento da depressão resistente: revisão integrativa
Revista Brasileira Militar de Ciências March 12, 2026 Tiago de Souza Santos, Joatan Lucas de Sousa Gomes Costa, Carmem Lúcia de Arroxelas Silva
Depression is a prevalent and disabling mental disorder considered a public health problem. It is characterized by persistent depressed mood, loss of interest in daily activities, cognitive and somatic changes, and often accompanied by fatigue, sleep or appetite disturbances. About 20–40% of patients with major depressive disorder do not respond adequately to conventional pharmacological treatment and are classified as having treatment-resistant depression (TRD). Psilocybin, a tryptamine alkaloid found in hallucinogenic mushrooms of the species Psilocybe mexicana, acts as a partial agonist of serotonin 5-HT2A receptors in the brain, altering perception, mood, and thought.