Qingqin S. Li

Genome-wide association study and polygenic risk score analysis of esketamine treatment response

Scientific Reports July 28, 2020 Qingqin S. Li, Ewa Wajs, Rachel Ochs-Ross et al. 49 citations

Abstract To elucidate the genetic underpinnings of the antidepressant efficacy of S-ketamine (esketamine) nasal spray in major depressive disorder (MDD), we performed a genome-wide association study (GWAS) in cohorts of European ancestry (n = 527). This analysis was followed by a polygenic risk score approach to test for associations between genetic loading for psychiatric conditions, symptom...