Ketamine for rapid reduction of suicidal ideation: a randomized controlled trial
Psychological Medicine August 12, 2015 James W. Murrough, Laili Soleimani, Kaitlin E. DeWilde et al. 297 citations
BACKGROUND: Suicide is a devastating public health problem and very few biological treatments have been found to be effective for quickly reducing the intensity of suicidal ideation (SI). We have previously shown that a single dose of ketamine, a glutamate N-methyl-d-aspartate (NMDA) receptor antagonist, is associated with a rapid reduction in depressive symptom severity and SI in patients with...