Toxicity of methylenedioxymethamphetamine (MDMA) in the dog and the rat.
Fundamental and applied toxicology : official journal of the Society of Toxicology July 1, 1987 C H Frith, L W Chang, D L Lattin et al.
MDMA given orally to dogs and rats for 28 days caused clinical signs like hyperactivity, dilated pupils, and salivation. Medium and high doses led to significantly less weight gain in both species, with initial decreased food consumption that later reversed. In dogs, reduced testicular size and prostatic enlargement occurred at medium and high doses, with testicular atrophy and prostatic hyperplasia seen microscopically. In rats, some clinical pathology values decreased (urinary pH, blood urea nitrogen, glucose, creatinine, LDH, chloride) while others increased (white blood cell count, phosphorus). No brain lesions were found in either species.