Lutz Leistritz

REM density predicts rapid antidepressant response to ketamine in individuals with treatment-resistant depression.

Neuropsychopharmacology May 1, 2025 Mina Kheirkhah, Wallace C. Duncan, Qiaoping Yuan et al. 6 citations

Abnormalities during rapid eye movement (REM) sleep contribute to the pathophysiology of major depressive disorder (MDD), but few studies have explored the relationship between REM sleep and treatment-resistant depression (TRD). In MDD, REM sleep abnormalities often manifest as alterations in total night REM Density (RD), RD in the first REM period (RD1), and REM Latency (RL). Among these, RD1...