Ketamine does not rescue plaque load or gap detection in the 5XFAD mouse model of Alzheimer's disease.
Frontiers in Aging Neuroscience 2025 Alexa L Wright, Aldis P Weible, Olivia B Estes et al. 1 citation
Ketamine has received growing attention for its effects on neuroplasticity and neuroinflammation, and as a treatment for depression and other mental health disorders. Recent evidence suggests that early sensory and behavioral deficits in Alzheimer's disease could be caused by synaptic disruption that occurs before irreversible neuropathology. This raises the possibility that ketamine could slow...