Glutamate in Salience Network Predicts BOLD Response in Default Mode Network During Salience Processing
Frontiers in Behavioral Neuroscience October 2, 2019 F. von Düring, I. Ristow, M. Li et al.
Glutamate concentration in the dorsal anterior cingulate cortex (dACC) modulates brain response during salience processing. In 27 healthy subjects, higher glutamate levels in the dACC balanced the attenuation of deactivation in the posterior cingulate cortex (PCC) caused by stimulus salience, such as sexual content or unexpected emotional content. This suggests that glutamate in the dACC plays a regulatory role in how the brain processes salient stimuli.